Links Scientific Reports

Is it Time for Reviewer 3 to Request Human Organ Chip Experiments

Instead of Animal Validation Studies?

(Advanced Science, online version, 2020 Oct)
Donald E. Ingber

Alzheimer’s Disease, and Breast and Prostate Cancer Research:

Translational Failures and the Importance to Monitor Outputs

and Impact of Funded Research

(Animals, 2020 Jul)

F.Pistollato et al.

Towards an animal-free human health assessment: Starting from

the current regulatory needs

(Altex 37, 2020 Jul)

Bos, Geraets. de Wit-Bos, Heringa, van Engelen

Tradition, not science, is the basis of animal model selection

in translational and applied research

(Altex, 2020 Jun)

Veening-Griffioen, Ferreira, Boon, Gispen-de Wied, Schellekens. Moors, van Meer.

Which is More Dangerous: Wildlife Markets or Animal Research?

(Animal Interfaith Alliance, 2020 May)

André Ménache

Harnessing the power of novel animal-free test methods for

the development of COVID-19 drugs and vaccines

(Archives of Toxicology 94, 2020 May)
François Busquet, Thomas Hartung, Giorgia Pallocca, Costanza Rovida & Marcel Leist

EURL ECVAM Recommendation on Non-Animal Antibodies

Publication Office of the EU, 2020 May)

Halder, Barroso, Whelan

The rapid development of computational toxicology

(Archives of Toxicology, 2020 May)

Hermann M.Bolt, Jan G. Hengstler

Corona Virus and Animal Testing

(Animal Interfaith Alliance, 2020 Apr)

André Ménache

It’s Time to Reconsider "The Principles of Humane Experimental Technique”

(ATLA, 2020 Apr)

Michael Balls

New European Union statistics on laboratory animal use - what really counts!

(Altex, 2020 Mar)

Busquet, Kleensang, Rovida, Herrmann, Leist, Hartung

Increasing the use of animal-free recombinant antibodies

(Altex, 2020 Mar)

Groff, Allen Casey, Clippinger

Toxicity testing in the 21st century; progress in the past decade

and future perspectives

(Archives of Toxicology, 2019 Dec)

D.Krewski / Thomas Hartung et al.

How viable are alternatives to animal testing in determining

the toxicities of therapeutic drugs?

(Editorial - Expert Opin Drug Metab Toxicol., 2019 Nov)

Michael Balls, Jarrod Bailey, Robert D Combes

Recent efforts to elucidate the scientific validity of animal-based drug tests

by the pharmaceutical industry, pro-testing lobby groups,

and animal welfare organisations

(BMC Med Ethics, 2019 Mar)

Jarrod Bailey, Michael Balls

Organ-on-chip in Development: Towards a Roadmap

for Organs-on-Chip/Meeting Report

(Altex, 2019 Oct)

Mastrangeli, Millet, the ORCHID partners, J. van den-Eijnden-van Raaij

Animal testing and its alternatives - the most

important omics is economics

(Altex, 2018 - NCBI)

Meigs L, Smirnova L, Rovida C, Leist M, Hartung T

Ethical and scientific Pitfalls concerning Laboratory Research

with Non-Human Primates, and Possible Solutions

(Animals, 2018, Dec)

Constança Carvalho et al.

Advances in neuroscience imply that harmful experiments in dogs are unethical

(J Med Ethics, 2018 Jan)

Jarrod Bailey, Shiranee Pereira

Human Stakeholders and the Use of Animals in Drug Development

(Business and Society Review, 2018)

Lisa A. Kramer, Ray Greek

Undervaluation of suffering of experimental animals in Germany

(ALTEX 3/2017)

Silke Strittmatter / Doctors Against Animal Experiments, Germany

Opinion versus evidence for the need to move away from animal testing

(ALTEX 2/2017)

Thomas Hartung

The need for strategic development of safety sciences

(ALTEX 1/2017)

Francois Busquet, Thomas Hartung

EU statistics on animal experiments for 2014

(ALTEX 4/2016)

Katy Taylor, Laura Rego

The European Citizens’ Stop Vivisection Initiative and the Revision of

Directive 2010/63/EU
(ATLA 44, 2016)

Dr. André Menache

Non-human primates in neuroscience research:
The case against its scientific necessity
(Altern Lab Anim., march 2016)

Dr. Bailey J., Dr Taylor K.

Adverse Outcome Pathways- Organizing Toxicological Information

to Improve Decision Making

(The Journal of Pharmacology and Experimental Therapeutics, 2016 Jan)

U.S. Government Agencies

Modelling the Tox21 10k chemical profiles for in vivo toxicity prediction
and mechanidm characterization
(Nature Communication, January 2016)

Dr. Ruili Huang

Predicting human drug toxicity and safety via animal tests: can any other species

predict drug toxicity in any other, and do monkeys help?

(Alter Lab Anim, Dec 2015)

Bailey j, Thew M, Balls M

The extreme consequences of naivety, ignorance of current science,

and lack of critical thinking skills in the animal protection community, part 1

(A.F.M.A., November 2015)

Dr. Ray Greek

Moving beyond animal models

(The Turkish Journal of Gastroenterology)

Hakan Şentürk

The Flaws and Human Harms of Animal Experimentation

( 2015 Oct)

Aysha Akhtar

Reproducibility: Standardize antibodies used in research

(Nature, Febrary )

Andrew Bredbury & Andreas Pluckthum

An analysis of the use of animal models in predicting human toxicology

and drug safety

( 2014 Jun)

Bailey J, Thew M, Balls M

Monkey-based Research on Human disease: The Implications of

Genetic Differences

(ATLA 42, 2014)

Jarrod Bailey

A Discussion of the Role of Complex Evolved Systems in the Development of

Invasive Cardiovascular Interventions as Illustrated by the Blalock-Taussig Shunt

and Intra-Arterial Stents

(Biological Systems, 2014)

Ray Greek

Monkey-based research on human disease: the implications of genetic difference

(Altern Lab Anim, 2014)

Jarrod Bailey

The Ethical Implications for Humans in Light of the Poor Predictive Value

of Animal Models

(International Journal of Clinical Medicine, Vol.5 No.16, 2014)

Ray Greek

Is animal research sufficiently evidence based to be a cornerstone of

biomedical research?

(TheBMJ, 2014)

Pound P, Bracken Michael B, Dwight Bliss S

EU statistics on animal experiments for 2014

(ALTEX 4/2016)

Katy Taylor, Laura Reg

Evolution and animal models

(Jama Neurol., 2013 Feb)

Lawrence A Hansen, Ray Greek

Genomic responses in mouse models poorly mimic human inflammatory diseases

(PNAS 2013 ; published ahead of print February 11, 2013)

Junhee Seok, H. Shaw Warren, Alex G. Cuenca, Michael N. Mindrinos, Henry V. Baker, Weihong Xu, Daniel R. Richards, Grace P. McDonald-Smith, Hong Gao, Laura Hennessy, Celeste C. Finnerty, Cecilia M. López, Shari Honari, Ernest E. Moore, Joseph P. Minei, Joseph Cuschieri, Paul E. Bankey, Jeffrey L. Johnson, Jason Sperry, Avery B. Nathens, Timothy R. Billiar, Michael A. West, Marc G. Jeschke, Matthew B. Klein, Richard L. Gamelli, Nicole S. Gibran, Bernard H. Brownstein, Carol Miller-Graziano, Steve E. Calvano, Philip H. Mason, J. Perren Cobb, Laurence G. Rahme, Stephen F. Lowry, Ronald V. Maier, Lyle L. Moldawer, David N. Herndon, Ronald W. Davis, Wenzhong Xiao, Ronald G. Tompkins, and the Inflammation and Host Response to Injury, Large Scale Collaborative Research Program

Inflammatory findings on species extrapolations: humans are definitely

no 70-kg mice

(Arch Toxicol. 2013 Apr;87(4):563-7. Epub 2013 Mar 19)

Leist M, Hartung T.

Systematic Reviews of Animal Models: Methodology versus Epistemology

(Int J Med Sci. 2013; 10(3): 206–221. Published online 2013 January 11)

Ray Greek and Andre Menache

SCIENCE CORRUPTED. Revealed: the nightmare world of GM mice *

(Animal Aid, 2013)

Researched and written by Dr Adrian Stallwood

* Italian version available here

The Nuremberg Code subverts human health and safety by requiring

animal modeling *

(BMC Medical Ethics 2012)

Greek R., Pippus A. and Hansen A.L.

Italian version available here

Robot Allows High-Speed Testing of Chemicals

(Scientific American October 13, 2011)

David Biello

Victims of Charity. A report on the cruel and scientifically invalid

experiments funded by medical research charities *

(Animal Aid, 2011)

Researched and written by Dr Adrian Stallwood and André Ménache

Italian version available here

Spanish version available here

Is the use of sentient animals in basic research justifiable?

(Philos Ethics Humanit Med. 2010 Sep 8; 5-14)

Greek R, Greek J.

Can animal models of disease reliably inform human studies?

(PLoS Med 2010, 7)

van der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, O’Collins V et al.

Per aspirin ad astra…

(Altern Lab Anim. 2009 Dec;37 Suppl 2:45-7. CAAT, Johns Hopkins University, Baltimore, USA)

Hartung T.

Are animal models predictive for humans?

(Philos Ethics Humanit Med. 2009 Jan 15; 4:2)

Shanks N, Greek R, Greek J.

Toxicology for the twenty-first century

(Nature 460, 208-212, 9 July 2009)

Thomas Hartung

Non-animal methodologies within biomedical research and toxicity testing

(ALTEX. 2008;25(3):213-31)

Knight A.

Of mice and men: the potential of high resolution human immune cell

assays to aid the preclinical to clinical transition of drug development projects

(Drug Discovery world 2008/9:74-78)

Brady C.A.

A prescription for human immunology

(Immunity. 2008 Dec 19;29(6):835-8)

Davis MM

Animal experiments scrutinised: systematic reviews demonstrate poor

human clinical and toxicological utility

(ALTEX. 2007;24(4):320-5)

Knight A.

Translation of research evidence from animals to humans

(JAMA 2006;296(14):1731-2)

Hackam & Redelmeier

A critical look at animal experimentation *

(Medical Research Modernization Committee, 2006)

Christopher Anderegg, Kathy Archibald, Jarrod Bailey, Murry J. Cohen, Stephen R. Kaufman, John J. Pippin

Italian version available here

Which drugs cause cancer? Animal tests yield misleading results

(BMJ USA 2005; 331: E389-E391)

Knight A, Bailey J, Balcombe J.

Where is the evidence that animal research benefits humans?

(BMJ. 2004 February 28; 328(7438): 514–517)

Pandora Pound, research fellow,1 Shah Ebrahim, professor,1 Peter Sandercock, professor,2 Michael B Bracken,professor,3 Ian Roberts, professor,4 and Reviewing Animal Trials Systematically (RATS) Group

Laboratory routines cause animal stress

(Contemp Top Lab Anim Sci. 2004 Nov;43(6):42-51)

Balcombe JP, Barnard ND, Sandusky C.

Are animal tests inherently valid?

(ATLA: Alternatives to Laboratory Animals, 32(Suppl. 1B), 755–758)

Balls, M. (2004)

Volunteer Studies Replacing Animal Experiments in Brain Research

(ATLA 28, 315–331, 2000, 315)

Report and Recommendations of a Volunteers in Research and Testing Workshop Gill Langley, Graham Harding, Penny Hawkins, Anthony Jones, Carol Newman, Stephen Swithenby, David Thompson, Paul Tofts and Vincent Walsh

Animal research is wasteful and misleading

(Scientific American, 00368733, Feb97, Vol. 276, Issue 2)

Barnard, Neal D., Kaufman, Stephen R.

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